The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development

The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development

Blog Article

Type 2 diabetes (T2D) has increased worldwide at an alarming rate.Metabolic syndrome (MetS) is a major risk factor for T2D development.One of the main reasons for the abrupt rise in MetS incidence, besides a sedentary lifestyle, is the westernized diet consumption, with high content of industrialized foods, rich in added dietary sugars (DS), mainly sucrose depileve easy clean and fructose.

It has been suggested that a higher intake of DS could impair metabolic function, inducing MetS, and predisposing to T2D.However, it remains poorly explored how excessive DS intake modulates mitochondrial function, a key player in metabolism.This review explores the relationship between increased consumption of DS and mitochondrial dysfunction associated with T2D development, diegojavierfares.com pointing to a contribution of the diet-induced accumulation of advanced glycation end-products (AGEs), with brief insights on the impact of maternal high-sugar diet and AGEs consumption during gestation on offspring increased risk of developing T2D later in life, contributing to perpetuate T2D propagation.